%PDF-1.4
%
113 0 obj
<>
endobj
110 0 obj
<>stream
application/pdf
BLOOD593202 753..761
2015-01-07T12:44:06+05:30
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2015-03-02T01:47:16-08:00
2015-03-02T01:47:16-08:00
Acrobat Distiller 10.1.8 (Windows)
uuid:5ed80731-e55b-4454-b897-c14f4ff72dbe
uuid:2fc060fa-1dd2-11b2-0a00-14f608a3b8ff
endstream
endobj
107 0 obj
<>
endobj
109 0 obj
<>
endobj
114 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 98 0 R/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 99 0 R/Type/Page>>
endobj
7 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/Properties<>/XObject<>>>/Rotate 0/Thumb 100 0 R/Type/Page>>
endobj
22 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 101 0 R/Type/Page>>
endobj
34 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 102 0 R/Type/Page>>
endobj
45 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 103 0 R/Type/Page>>
endobj
56 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 104 0 R/Type/Page>>
endobj
66 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 105 0 R/Type/Page>>
endobj
74 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Thumb 106 0 R/Type/Page>>
endobj
171 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
207 0 obj
[211 0 R 212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R 222 0 R 223 0 R]
endobj
208 0 obj
<>stream
q
180.0018311 0 0 42.6004333 72 667.3995667 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
10 0 0 10 262 659.99988 Tm
(online November 20, 2014)Tj
15.62098 1 Td
( originally published)Tj
/T1_1 1 Tf
-15.62098 0 Td
(doi:10.1182/blood-2014-08-593202)Tj
0 1.00001 TD
(2015\240125: 753-761)Tj
/T1_0 1 Tf
0 1 TD
(\240)Tj
T*
(\240)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 72 561.99979 Tm
(Eibel, Gabriele Niedermann, Orly Elpeleg and Stephan Ehl)Tj
T*
(Molho Pessach, Arndt Borkhardt, Mirzokhid Rakhmanov, B\344rbel Keller, K\
laus Warnatz, Hermann)Tj
0 1.00001 TD
(Nabhani, Fabian Beier, Tim H. Br\374mmendorf, Sebastian Fuchs, Simon Zen\
ke, Elke Firat, Vered )Tj
0 1 TD
(Polina Stepensky, Anne Rensing-Ehl, Ruth Gather, Shoshana Revel-Vilk, Ut\
e Fischer, Schafiq)Tj
T*
(\240)Tj
/T1_2 1 Tf
13 0 0 13 72 611.99994 Tm
(immunosenescence associated with tripeptidyl-peptidase II deficiency)Tj
T*
(Early-onset Evans syndrome, immunodeficiency, and premature)Tj
/T1_1 1 Tf
T*
(\240)Tj
ET
72 528 m
521 528 l
0 0 m
S
BT
0 0 1 rg
/T1_2 1 Tf
10 0 0 10 72 503.99994 Tm
(http://www.bloodjournal.org/content/125/5/753.full.html)Tj
0 g
/T1_1 1 Tf
T*
(Updated information and services can be found at:)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 150.36005 439.99985 Tm
( \(0 articles\))Tj
0 0 1 rg
-6.836 0 Td
(Plenary Papers)Tj
0 g
/T1_0 1 Tf
-1 0 Td
(\240\240\240 )Tj
/T1_1 1 Tf
10.50299 1 Td
( \(393 articles\))Tj
0 0 1 rg
-9.50299 0 Td
(Pediatric Hematology)Tj
0 g
/T1_0 1 Tf
-1 0 Td
(\240\240\240 )Tj
/T1_1 1 Tf
7.77998 1.00001 Td
( \(5277 articles\))Tj
0 0 1 rg
-6.77998 0 Td
(Immunobiology)Tj
0 g
/T1_0 1 Tf
-1 0 Td
(\240\240\240 )Tj
/T1_1 1 Tf
11.16898 1 Td
( \(2988 articles\))Tj
0 0 1 rg
-10.16898 0 Td
(Free Research Articles)Tj
0 g
/T1_0 1 Tf
-1 0 Td
(\240\240\240 )Tj
/T1_1 1 Tf
15.05898 1 Td
( \(4040 articles\))Tj
0 0 1 rg
-14.05898 0 Td
(Clinical Trials and Observations)Tj
0 g
/T1_0 1 Tf
-1 0 Td
(\240\240\240 )Tj
/T1_1 1 Tf
0 1.00001 TD
(Articles on similar topics can be found in the following Blood collectio\
ns)Tj
ET
72 423 m
521 423 l
0 0 m
S
BT
0 0 1 rg
/T1_2 1 Tf
10 0 0 10 72 398.99994 Tm
(http://www.bloodjournal.org/site/misc/rights.xhtml#repub_requests)Tj
0 g
/T1_1 1 Tf
0 1 TD
(Information about reproducing this article in parts or in its entirety m\
ay be found online at:)Tj
ET
BT
0 0 1 rg
/T1_2 1 Tf
10 0 0 10 72 360.99997 Tm
(http://www.bloodjournal.org/site/misc/rights.xhtml#reprints)Tj
0 g
/T1_1 1 Tf
T*
(Information about ordering reprints may be found online at:)Tj
ET
BT
0 0 1 rg
/T1_2 1 Tf
10 0 0 10 72 322.99997 Tm
(http://www.bloodjournal.org/site/subscriptions/index.xhtml)Tj
0 g
/T1_1 1 Tf
T*
(Information about subscriptions and ASH membership may be found online a\
t:)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
10 0 0 10 72 41.99991 Tm
(\240 )Tj
T*
(Copyright 2011 by The American Society of Hematology; all rights reserve\
d.)Tj
0 g
0 1.00001 TD
(of Hematology, 2021 L St, NW, Suite 900, Washington DC 20036.)Tj
0 1 TD
(Blood \(print ISSN 0006-4971, online ISSN 1528-0020\), is published week\
ly by the American Society)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
9 0 0 9 348.77577 766 Tm
(For personal use only.)Tj
0 g
-8.33798 0 Td
(on March 2, 2015. )Tj
-4.058 0 Td
(by guest )Tj
/T1_0 1 Tf
8 0 0 8 235.21202 766 Tm
( )Tj
0 0 1 rg
/T1_1 1 Tf
9 0 0 9 148.68617 766 Tm
(www.bloodjournal.org)Tj
0 g
-2.61097 0 Td
(From )Tj
ET
endstream
endobj
210 0 obj
<>/Filter/FlateDecode/Height 71/Length 14105/Name/X/Subtype/Image/Type/XObject/Width 300>>stream
HgXTgǧwqMA,h%Vj}k,f튝UQIYdI챣` ֥(@TT@0)03Lo!(Ͻ}?EQ&Ll'c&
c=V'Tciӡz=Bɶ+\Z
D:Ƿ13vGtZDo
$O x!FJ#cF:/2Eȿ
ڽǶ4>+^Lfq>six0h5u7_=,"ۏ8Dsq}dk2 (x"zJ}^r~QaoL4-{5!z|w岺O SgSHI<>?IAF^&;wXcx0qIvvaYwozZTw:k(* F~y\{L(\s/%5>1yjy@"8KDb]S%E^OHqRaGOvqVvoGķoĢOLi֊bJZXssh8_;AiQ3Ee_5U^_dpxQn~LРNΦ[q^8/7hcpU$2ۧSQc/J'_M{ǠTA?KPZO2\R20b` ቤ0X-
@;zYMӡ&{8T?`eu}mM3RleҊ_.X
VNӃdk@jF
u\UG]b{d"H4Q]O s$
<̀wZRռ=eBOH
<\B]WG -uPZFM{zAMp,@0^p\S?N?:ӣEQؿ.0%2wB^yWEˠ&lVS~RT;LbYb\j'gbAbgȠ^*f٣߬)xV(
{NN iz'TJ`^v9{/fwpH+eGֆBqgִ.բ*X+"ܯ:zpP<
ѯ?\e]&EEQۂטxiC"f!^gy^av=?$ۛGŠ0gͿLe]OG