Alternating Hemiplegia (AHC) Community

Here's a selection of information from patients & professionals to better understand Alternating Hemiplegia (AHC).

The resources in this section have been provided by the patient organizations that specialize in Alternating Hemiplegia and other relevant documents, useful links, and brochures.

  • Recognizable Facial Features in Patients with Alternating Hemiplegia of Childhood

    We performed a morphological evaluation of 30 patients at different ages. All patients were evaluated independently by each author and evaluation sheets were compared, discussed, and agreed afterwards. This study started before the identification of ATP1A3 as the causative gene, and the patients were selected upon their neurological picture.

    Author/Foundation: American Journal of Medical Genetics

    Year of publication: 2016, English

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  • A novel recurrent mutation in ATP1A3 causes CAPOS syndrome

    Provisional PDF, originally published online here:
    http://www.ojrd.com/content/9/1/15/abstract

    Author/Foundation: Michelle K Demos, Clara DM van Karnebeek, et al.

    Year of publication: 2014, English

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  • Asystole in alternating hemiplegia with de novo ATP1A3 mutation

    Author/Foundation: Jan Novya, Eric McWilliams, Sanjay M. Sisodiya

    Year of publication: 2014, English

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  • Alternating hemiplegia of childhood: New diagnostic options

    A syndrome of alternating hemiplegia of childhood (AHC) is a rare disorder first presented in 1971. AHC is characterized by transient episodes of hemiplegia affecting either one or both sides of the body. Age of onset is before 18 months and the common earliest manifestations are dystonic or tonic attacks and nystagmus. Hemiplegic episodes last minutes to days and the frequency and duration tend to decrease with time. Motor and intellectual development is affected, deficits may also develop later. Epileptic seizures occur in some patients. Neuroimaging of the brain usually reveals no abnormalities. The variability of individual clinical presentations and evolution of symptoms have made diagnosis difficult. Therefore the problems of misdiagnosis could account for the low prevalence of this syndrome. This paper hopes to present actual data on AHC, especially of the results of genetic research and new diagnostic tools.

    Author/Foundation: Aleksandra Gergont; Marek Kaciński

    Year of publication: 2014, English

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  • Distinct neurological disorders with ATP1A3 mutations

    Author/Foundation: Heinzen EL, Arzimanoglou et al.

    Year of publication: 2014, English

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