Acute Necrotizing Encephalopathy ANE (or Genetic ANE1) is also known as Infection Induced Acute Encephalopathy (IIAE3), OMIM No. 608033. It is also known as ADANE and ANEC. Orpha No. 88619.
Familial acute necrotizing encephalopathy or ADANE is a potentially fatal neurological disease characterised by neuropathological lesions principally involving the brainstem, thalamus and putamen. Onset occurs during early childhood, typically a few days after a febrile illness. Manifestations include vomiting, seizures, spasticity, language regression, rigidity and abnormal posturing of the head. Residual neurologic impairment (muscle weakness, speech disturbance, intellectual deficit and mood disorders) persists in some patients. The disease is chronic in one out of two cases.