Clinical Trials FMF

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  Efficacy and Safety of Canakinumab in Patients With Colchicine Resistant Familial Mediterranean Fever
  Google BlogSearch, 2011-05-09 00:00:00

  
  Establish the safety and efficacy of 3 months treatment with canakinumab in patients with colchicine resistant Familial Mediterranean Fever...
  

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  Pharmacokinetics Study of Colchicine in Familial Mediterranean Fever (FMF) Patients
  FMF Clinical Trials, 2011-04-21 00:00:00

  
  ...The primary objective of this study is to evaluate and compare the steady-state pharmacokinetics of multiple oral doses of colchicine sprinkle capsules administered to pediatric and adult FMF patients...
  

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  http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00001373
  Recent scientific publications, 2011-04-21 00:00:00

  
  This study is designed to explore the genetics involved in diseases of intermittent fever, including familial Mediterranean fever, TRAPS, hyper-IgD syndrome, and related diseases.
  

Clinical Trials FMF 2

FMF Research

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  Anti-TNF agents in familial Mediterranean fever: report of three cases and review of the literature
  Google BlogSearch, 2011-05-20 00:00:00

  
  Herein we present reports of three patients (all were positive for HLA B27) with typical spondylitis associated with FMF who were successfully managed with anti-TNF agents, along with a literature review.
  

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  Familial Mediterranean Fever and Hypercoagulability
  Google BlogSearch, 2011-05-17 00:00:00

  
  Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which is characterized by recurrent attacks of fever and peritonitis, pleuritis, arthritis, or erysipelas-like skin disease. As such, FMF is a prototype of autoinflammatory diseases...
  
  

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  Coexistence of vasculitides with Familial Mediterranean Fever
  Google BlogSearch, 2011-05-09 00:00:00

  
  Abstract

  Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by recurrent self-limited attacks of fever accompanied with peritonitis, pleuritis, or arthritis. FMF may coexist with various systemic..
  

FMF Research 2

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  Normal autonomic nervous system responses in uncomplicated familial Mediterranean fever: a comparative case-control study.
  Google BlogSearch, 2011-05-06 00:00:00

  
  There is a paucity of knowledge regarding the autonomic nervous system function in patients with familial Mediterranean fever (FMF). Therefore, our aim was to evaluate autonomic responses in patients with FMF using complementary tests...
  

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  Clinical and Experimental Rheumatology - Behçet's disease and other autoinflammatory conditions
  FMF Medworm, 2011-03-16 00:00:00

  
  Links to free, full text articles on FMF. With articles including:

  Association of familial mediterranean fever and celiac disease in a 14-year-old girl with recurrent arthritis

  Relapsing polychondritis in a patient with familial Mediterranean fever and amyloidosis

  Familial Mediterranean fever. A bird`s eye review of the recent literature

  ...any many more!

  Articles from 2006 here: http://www.clinexprheumatol.org/a.asp?IDArchivio=71&Free=1
  

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  Shar-Pei dogs and FMF
  Google BlogSearch, 2011-03-16 00:00:00

  
  Though more research is needed, the HA pathway may represent a new trigger for the 60% of repetitive human fever illnesses without a known cause, such as Familial Mediterranean Fever. The Broad/Uppsala team is now following up on this potential link in human patients.
  

FMF Research 3

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  Novel Protagonists in Autoinflammatory Arthritis of Familial Mediterranean Fever
  Google BlogSearch, 2011-06-08 00:00:00

  
  Case report abstract
  

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  The familial Mediterranean fever gene as a modifier of periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome.
  Recent scientific publications, 2011-06-06 00:00:00

  
  PATIENTS AND METHODS:

  The cohort of this ongoing prospective study consisted of 124 children with PFAPA syndrome, followed in a single referral center, who were tested for MEFV mutations. Demographic data, clinical characteristics, and disease course of 65 PFAPA patients with and 59 without MEFV mutations (M+ and M-, respectively) were compared.
  

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  Researchers identify key to molecular signals in disease affecting Mediterranean populations
  Google BlogSearch, 2011-06-06 00:00:00

  
  National Institutes of Health researchers studying familial Mediterranean fever (FMF) — a rare genetic disorder that causes patients to experience seemingly unprovoked recurring episodes of fever — have discovered a novel pathway that triggers inflammation in these patients.
  

FMF Research 4

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  Saturday night fever: bizarre recurrence of fever attacks in a patient carrying a mutation in both the MEFV and TNFRSF1A genes
  Recent scientific publications, 2012-02-01 00:00:00

  
  Letter to the editor, free full text
  

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  Dramatic beneficial effect of interleukin-1 inhibitor treatment in patients with familial Mediterranean fever complicated with amyloidosis and renal failure FMF complicated with amyloidosis and treated with anakinra.
  Recent scientific publications, 2011-09-27 00:00:00

  
  Abstract only
  

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  The regulation of MEFV expression and its role in health and familial Mediterranean fever
  Recent scientific publications, 2011-07-25 00:00:00

  
  Abstract only
  

FMF Treatments

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  An Old Gout Drug Gets New Life and a New Price, Riling Patients
  Google BlogSearch, 2010-04-12 00:00:00

  
  By JONATHAN D. ROCKOFF

  A centuries-old drug used to treat excruciating gout pain had cost just pennies a tablet—until last year. Now, the retail price has skyrocketed to more than $5 and some of the manufacturers have ceased production amid a battle over marketing rights.

  The tale of how this common gout drug, colchicine, became the costlier branded drug Colcrys offers a window into the Byzantine world of drug pricing. The price rise is a consequence of a Food and Drug Administration effort to improve the safety of long-used but unapproved drugs, with a trade-off often made between drug affordability and safety.
  

General Info.

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  Parsing familial Mediterranean fever, beta thalassemia and Munchausen syndrome by proxy.
  Google BlogSearch, 2011-05-29 00:00:00

  
  The show's portrayal of familial Mediterranean fever is limited, says Dr. Wayne Grody, professor of medical genetics and molecular pathology at UCLA and a world expert in FMF.
  

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  Febbre Mediterranea Familiare, una malattia "antica"
  Google BlogSearch, 2011-04-21 00:00:00

  
  La FMF fa parte di un gruppo di malattie rare, definite auto infiammatorie. Ne soffrono circa un migliaio di persone in Italia, concentrate in particolare nelle regioni del Sud. Ma il dato è sottostimato, vista la difficoltà di una diagnosi immediata.
  

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  Rash Pattern and Duration Distinguish Hereditary Periodic Fever Syndromes
  Google BlogSearch, 2011-02-16 00:00:00

  
  Familial Mediterranean fever. The rash of FMF is usually stationary. Sometimes called erysipeloid erythema, the rash is reddish, raised, usually well demarcated, and sometimes painful. It often occurs on the dorsum of the foot, ankle, or lower leg.

  The attacks typically last 1-3 days and occur on a monthly basis. These attacks are characterized by fever and rash accompanied by various kinds of inflammation, including pleural inflammation with effusion; massive joint effusions; and a nonerosive, nondeforming, monoarticular arthritis.

  "Many of these patients have such severe abdominal pain during attacks that early in their disease they’re mistaken for appendicitis and undergo at least one exploratory laparotomy," according to Dr. Kastner.
  

Links for Parents of Children with FMF

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  Case History of Child with FMF
  Google BlogSearch, 2008-04-19 00:00:00

  
  From the Online Case Library, a Case Presentation from Fellows of the Salzburg Medical Seminars International.

  
  Powerpoint presentation from 2008.