Do any of you that have CAPS in your family have some people that are more affected than others in the family?

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  AllieFreitas | published 4 months ago | Originally written in English Do any of you that have CAPS in your family have some people that are more affected than others in the family?

  This abstract is about 2 siblings with atypical mutations for CAPS, and one sibling had more symptoms than the other, even with the same mutation.

  www.ncbi.nlm.nih.gov/pubmed/20506209

  Thanks to Karen for passing this along!
  4 replies to the topic — see all replies

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    karend published 4 months ago | Originally written in English

    Thanks Allie for sharing it! I was planning on putting it on this community once I could find the entire article. I will see what I can do on that. I just went to the link again, and found that I can access the full article on the bottom of the page and it worked for me this time. Here is the link for the full article: onlinelibrary.wiley.com/doi/10.1002/art.27...

    Karen Durrant
  • 
    paul published 4 months ago | Originally written in French

    Hello Allie and Karen

    Happy new year at this start of 2012.

    I know a family which have MWS and don't hold the same perception of the disease

    All are cured with Kineret or Ilaris

    Some diseased have hearing aid, some don't have hearing problems.

    Before treatment (because now all of the other symptoms are gone), some had severe hives, some a lot less.

    Same thing with the joint pains conjunctivitis.

    Some also have mouth ulcers and eczema, some don't. Why ?

    No particular research was done on those symptoms differences.

    Yours truly,

    Paul

    Notice: This text content has been translated automatically by a third-party service.
  • 
    karend published 4 months ago | Originally written in English

    Dear Paul,

    Thanks for this comment, You do know first hand how much this disease can affect families in so many ways! It is very interesting that some people have eczema too, as my son has had that too. I have heard from others with it, and a few that also are suffering from mouth ulcers, which is not often noted in the medical literature. So this is very important information for patients to know that this is possible, and that they should mention it to their doctors! Thanks Paul. I am going to share that information with a few patients. Thanks to all that are sharing and helping with this very helpful forum for patients.

    Best wishes,

    Karen
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    carew52 published about 1 month ago | Originally written in English

    Speaking from our own family I have to say it does seem to present itself in slightly different ways in all of us. My sister is the only one so far with painful joints, I was the one who seemed to cop the fevers and nausia the worst and my Dad's hearing was shot pretty young. Our youngest and newest member, only a couple months old has yet to sign any sign of rash though his blood test is positive.