Abstract only from Newcastle researchers

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Abstract

Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Mutations in genes encoding regulators of the...

Abstract

Abstract only

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Free full text article

Free full text article

Abstract

Atypical hemolytic uremic syndrome (aHUS) is a rare form of complement dysregulation disease, and recently various reports have shown that it is associated with one or more mutations in the complement regulatory genes including...

Abstract

The atypical Hemolytic Uremic Syndrome (aHUS) is a rare thrombotic microangiopathy leading to end stage renal disease in approximately 60% of patients....

We report the efficacy of eculizumab in a patient who presented with a recurrence of atypical hemolytic syndrome at 3 years after renal transplantation. After 17 months of eculizumab treatment, and without concomitant plasma therapy, renal function was maintained, the need for blood transfusions reduced, and acute thrombotic microangiopathy and hemolysis controlled...

This study is currently recruiting participants

The record Primary purpose is to assess the efficacy of eculizumab in adult patients with aHUS to control TMA as characterized by thrombocytopenia, hemolysis and renal impairment.

Status: Recruiting, Condition Summary: Atypical Hemolytic-Uremic Syndrome

The primary purpose is to assess the efficacy and safety of eculizumab in pediatric patients with aHUS to control TMA as characterized by thrombocytopenia, hemolysis and renal impairment.

Status: Recruiting, Condition Summary: Atypical Hemolytic-Uremic Syndrome

Here is a parents-platform of HUS-kids in German.

Diese Seite soll eine Plattform sein für alle Eltern deren Kinder das HUS-Syndrom hatten oder daran erkrankt sind und auch für Eltern deren Kinder an chron. Niereninsuffizienz leiden und vor einer Transplantation stehen.

Mir ist es schon lange am Herzen gelegen so eine Plattform zu gründen, da ich selbst davon betroffen bin. Mehr dazu unter "Meine Geschichte"

Ich bin kein Arzt oder Mediziner, mir ist nur wichtig, dass alle Eltern die mit mir dieses schlimme Schicksal teilen, einen Ort haben an dem sie sich gegenseitig austauschen können, ihre Erfahrungen und Erlebnisse erzählen können und das Gefühl haben dürfen dieses Schicksal nicht alleine tragen zu müssen.

Mir ist wichtig zu erkennen, dass nicht nur unsere Kinder eine schlimme Zeit durmachen oder gemacht haben. Sondern auch die Personen die sie begleitet haben oder begleiten, grossem psychischen und körperlichen Stress ausgesetzt sind. Was gibt es schlimmeres als sein Kind auf der Intensiv-Station, beatmet und im Tiefschlaf liegen zu sehen. Hilflos dabei zu sehen und nichts machen zu können ausser da zu sein? Ich werde diese Zeit für immer mit mir tragen, sie ist zu einem Teil meines Leben´s geworden. Die Angst ist mein ständiger Begleiter, da uns die Nierentransplantation auch noch bevor steht.

Ich möchte mit dieser Seite, Eltern Mut machen weiter zu kämpfen und ihnen wirklich das Gefühl geben, dass ihr nicht alleine seit! GEMEINSAM sind wir stark und GEMEINSAM können wir uns gegenseitig unterstützen!
 

...The third annual Hike 4 Hyde at the Sawnee Mountain Preserve raised more than $26,000 for charity in honor of Hyde Talbot and another young boy in Georgia with atypical hemolytic-uremic syndrome, known as Atypical HUS...

When he was just 18 months old, Hyde was diagnosed with atypical HUS. Roughly 300-400 people in America have it -- a genetic disease that attacks the red blood cells and eventually destroys the kidneys and the immune system...

A youngster with a rare genetic disorder is back at school following a pioneering double transplant.

Four-year-old Riley Greenwood was the first child in the country with his condition to have a combined liver and kidney swap.

His parents say they rushed Isaiah to the hospital where doctors diagnosed him with a rare condition called Atypical Hemolytic Uremic Syndrome. They say Isaiah’s body was basically destroying his own red blood cells.

The group is being led by Tim Goodship, professor of renal medicine at The Institute of Human Genetics in Newcastle, who is internationally respected in the field of aHUS and was the first to identify the abnormality in complement that is thought to cause the disease.

Donations will benefit Chloe Peterson, 6, Omak. She suffers from Atypical Hemolytic Uremic Syndrome, which destroys her red blood cells. That clogs her kidneys, which could cause them to fail.

We present the first case of a young patient with aHUS who received eculizumab as prophylactic treatment prior to a successful kidney transplantation....

Total deficiency of complement factor H (CFH) is associated with dense deposit disease (DDD) and atypical haemolytic uraemic syndrome (aHUS). CFH is the major regulator of the alternative pathway of complement activation and its complete deficiency results in uncontrolled C3 activation through this pathway and secondary C3 deficiency